THE PASSIVE ANTI-TUMOR DEFENSE SYSTEM
Following years of research, dr. Gyula Kulcsár cancer researcher biochemist and medical university senior lecturer made a new scientific discovery regarding the anti-tumor defense mechanism of the human body: he realized that unlike what was known to scientists until then, it was not the immune system, but rather a special defense system that destroyed the cells that turned abnormal.
He worked out the theory and then through research started in 1987 he was able to prove the existence of the Passive Anti-Tumor Defense System (PADS) , and he also identified its components and mechanism. Through extensive research he came to the conclusion that substances constantly present in the circulatory system (i.e. some amino acids, certain vitamins, cell metabolism intermediaries etc.) played a major role in the protection against tumors. In cell cultures and animal studies he demonstrated the selective tumor-cell-killing effect of a blend of these active agents that make up the anti-tumor defense system of the body, and he published the results in international scientific publications. The patent based on dr. Gyula Kulcsár's discovery has been registered in a number of countries all over the world, from the European Union to Korea .
By synthesizing previously discovered scientific facts in a new way dr. Kulcsár was able to arrive at the conclusion that the anti-tumor defense mechanism of the body operates essentially independently of the immune system .
His research originated from the recognized scientific fact that only some kinds of tumor, mainly Kaposi's sarcoma and non‑Hodgkin's lymphoma has significantly increased incidence when the operation of the immune system is restricted (immunosuppression) or collapses completely (e.g.: AIDS).
It is also common knowledge that most of the tumors are not immunogenic. Accepting these facts and knowing that cancer cells are constantly produced in every one of us, one must assume the existence of an anti-tumor defense mechanism that operates independently of the immune system – as it must exert its effects in any point of the human body –, i.e. a ‘surveillance' system with overall effectiveness. Logically, the active agents of such a system must be located in the circulatory system.
According to dr. Kulcsár the key to the solution is another fact, which has also been known from earlier, notably that healthy cells take up the substances in the circulatory system in such quantities as are necessary for sustaining their life functions, while tumor cells accumulate these materials without limitations. Thus the substances playing a role in anti-tumor protection are taken up by tumor cells in such enormous quantities that result in the destruction of the abnormal cells.
This combined effect of the agents of the defense system, i.e. the active substances is now called Passive Anti-tumor Defense System (PADS) .
In his experiments, the inventor used the tumor cells themselves to select the really effective substances. By the selection criteria the really effective substances were those that destroyed the tumor cells – through a synergistic support of one another's effects. Dr. Kulcsár examined 89 substances in the circulatory system, and found that 16 of them were effective in this sense. Within the scope of active substances he identified amino acids with completely different chemical structures (methionine, phenylalanine, tryptophan, arginine, histidine, tyrosine), vitamins (ascorbic acid, riboflavin, pyridoxine, biotin), monosaccharides (mannose, deoxy-d-ribose), and inter-cellular intermediaries (malic acid, hippuric acid, orotic acid) and nucleobase (adenine).
Dr. Kulcsár carried out several experiments with a blend of these active substances. He found that the anti-tumor-cell effect was due to cell destruction ( direct effect ) rather than proliferation blocking. The blend was effective in all of the very different – more than ten and in most cases human – cell lines he tested ( general effect ). His blend was capable of destroying the cells that were resistant to cytostatics (i.e. chemotherapy). Furthermore, the blend preparation had no toxic effects on the healthy cells, not even on the rapidly dividing cells ( selective effect ). In summary, this active agent mix has direct, general and selective tumor-cell killing effects .
Animal studies performed by dr. Kulcsár have also demonstrated the anti-tumor effect of the blend preparation. Experiments with mice demonstrated significant improvement in survival and reduction in tumor growth.
The inventor carried out further cellular experiments to examine the mechanism of the blend's anti-tumor effect. He found that the cancer cells are destroyed through apoptosis, i.e. programmed cell death. The extent of apoptosis can be enhanced by increasing the quantity of active substances and the duration of their impact.
The conclusion to draw from the experimental results is that the stronger the protection (i.e. the greater the concentration of the active substances forming the defense system) the faster the cancer cell destruction, in other words the cell destruction rate depends on the concentration of protective materials.
Among the publications please read dr.Gyula Kulcsár's doctoral dissertation (in English) on the PADS .
